Abstrakt
Many authors encounter problems associated with insufficient mechanical properties, as the formed tissue is actually not resistant enough, or even earlier, when the cells are not forming optimally or do not grow adequately. This is caused by number of factors, such as suboptimal chemical - biological properties of the scaffold as well as its mechanical properties.
While electrospinning the nanofibers, many parameters can be adjusted, affecting the final properties of the nanofibers (manufacturing solution viscosity, voltage, collector type...). The electrospinning is also influenced by environmental conditions (i.e. temperature, humidity), as well as post-production processes (cross-linking...) [1,2].
It is evident from the available literature, that there is not a linear dependence on the properties of the nanofibres and the complex nanofibrous structure. These are characterized by their rheological inhomogenity and the available approaches used to study deformations omit detailed structural changes inside the material.
To produce scaffolds that satisfy all requirements of their use, it is necessary to identify all parameters and their mutual interactions to the partial and final qualities of scaffolds