A UHPLC-UV-QTOF study on the stability of carfilzomib, a novel proteasome inhibitor

Abstract

A new stability-indicating UHPLC-UV method for analysis of carfilzomib, a proteasome inhibitor drug, was developed and validated. The method was utilized to evaluate the effects of forced degradation and to investigate the degradation kinetics, as well asto examine drug stability in a pharmaceutical formulation.

In addition a UHPLC-QTOF method was used to identify the main degradation products.

Keywords

• Carfilzomib
• Degradation kinetics
• Proteasome inhibitor
• Stability indicating method
• Stress test
• UHPLC-UV- QTOF