Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders
Abstract
The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method.
Hypromelloses Methocel(TM) K4M Premium CR or Methocel(TM) K100M Premium CR were used as controlled release agents and Prosolv(R) SMCC 90 or Disintequik(TM) MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis.
The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined.
It was found that matrix tablets based on Prosolv(R) SMCC 90 and Methocel(TM) Premium CR cannot control the tramadol release effectively for > 12 h and tablets containing Disintequik(TM) MCC 25 and Methocel(TM) Premium CR > 8 h.