The effect of hypoxia and re-oxygenation on adipose tissue lipolysis in COPD patients

Abstract

Severe chronic obstructive pulmonary disease (COPD) is a progressive disease associated with excessive mortality; however, mechanisms driving disease progression remain unclear. A pro-inflammatory state, metabolic impairments and respiratory muscle weakness contribute to deterioration of lung function.

Furthermore, a poor COPD prognosis appears to be associated with unintentional weight loss, which has been observed in 50% of severe COPD patients.

Keywords

• obstructive pulmonary-disease
• prognostic value
• inflammation
• failure
• obesity