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Uric Acid as a Marker of Mortality and Morbidity in Fabry Disease

Publication at First Faculty of Medicine |
2016

Abstract

Background: Serum uric acid (UA) elevation is common in patients with cardiovascular, renal and metabolic diseases. However, no study to date has analysed the role of UA in Fabry disease (FD).

Objectives: To evaluate the association between serum UA levels and mortality and morbidity in FD. Materials and Methods: We conducted a post-hoc analysis of a prospectively followed-up cohort of 124 patients with genetically proven FD.

Serum UA levels were acquired at baseline; clinical events and mortality were assessed during regular visits every 6 to 12 months. The primary endpoint was a composite of multiple secondary outcomes: all-cause mortality, adverse cardiovascular events, progression of renal dysfunction and stroke or transient ischaemic attack (TIA).

Predictive value was assessed using the Cox proportional hazards model and the Kaplan Meyer estimator.