Correlations of clinical and biochemical findings in persons with elevated concentrations of apolipoprotein B48
Abstract
The elevated concentration of of apolipoprotein B48, which is specific structural spolipoprotein (apo) of the chylmicrons and their remnant particles, is considered as an independent risk factor of cardiovascular diseases. We compared persons characterized by the elevated concentration of of apo B48 (8,1 mg/l; n = 78) with the probands with normal concentration of of apo B48 (n = 93).
The proband with elevated apo B48 had significantly greater waist circumference, higher number of the metabolic syndrome components, higher prevalence of LDL phenotype B, of index HOMA-IR values, and the concentrations of plasma conjugated dienes and oxidatively modified LDL. In plasma phosphatidylcholine we found in the probands with elevated apo B48 higher concentration of stearic acid, higher estimated activity of D-9 desaturase with concomitant lower activity of D-5 desaturase.
Lower proportion of minor allele frequency of the single nucleotide polymorphisms of SCD-1 (rs2167444, rs508384) in the probands with elevated apo B48 implicates the participation of genetic factors in the pathogenesis of subgroup of metabolic syndrome patients characterized by the apo B48 elevation.