Microsatellite instability as a predictive factor for immunotherapy in malignant melanoma

Abstract

Immunotherapy has attracted attention as a novel treatment modality for malignant melanoma, one that may utilize the host's immune response against tumor cells. Although the use of immunotherapy in metastatic melanoma has shown promising results, the application of this modality in an adjuvant setting is still questionable.

There remains a lack of predictive biomarkers indicating treatment benefit from immunotherapy. However, there is growing evidence suggesting that microsatellite instability (MSI) may be one of possible predictive markers in malignant melanoma.

Keywords

• Microsatellite instability
• predictive factor
• immunotherapy
• malignant melanoma