Prognostic significance of expression of protein p53 in rectal cancer patients treated with postoperative adjuvant radiotherapy
Abstract
ackground: Tumor suppressor gene TP53 is one of the most frequently mutated genes in human tumors. The aim of the study was to assess the prognostic significance of the expression of the product of this gene-protein p53 in patients treated with postoperative adjuvant radiotherapy for locally advanced rectal adenocarcinoma.
Patients and methods: In total 59 patients with locally advanced rectal cancer were studied retrospectively. Results: The median expression of protein p53 was 70%.
Five-year overall survival according to the median expression of protein p53: p53 70 = 57%, logrank: p = 0,86; HR = 0,94. Five-year progression free survival (PFS) according to the median expression of protein p53: p53 70 = 49%, logrank: p = 0,92; HR = 0,97.
Conclusion: The results of this study demonstrate protein p53 expression in locally advanced rectal adenocarcinoma. This study did not show predictive or prognostic significance of expression of protein p53, which can be caused by a wide range of factors which influence the expression of protein p53.