The effect of lamotrigine and phenytoin on bone turnover and bone strength: A prospective study in Wistar rats

Abstrakt

Some data suggest that exposure to lamotrigine (LTD) might be associated with impaired bone health in an orchidectomized rat model. The aim of this study was to determine if LTG poses any significant risk for bone in a gonadally intact animals and to compare the effect of LTG with that of phenytoin (PHT).

Klíčová slova

• bone mineral density
• bone turnover markers
• bone alkaline phosphatase
• amino-terminal propeptide of procollagen type I
• osteoprotegerin/receptor activator of nuclear factor kappa B ratio
• sclerostin