Recommendations for the diagnosis and treatment of chronic lymphocytic leukaemia (CLL) Czech Group for Chronic Lymphocytic Leukaemia, section of the Czech Society of Haematology, CzMA
Abstract
Chronic lymphocytic leukaemia (CLL) has a remarkably heterogeneous clinical course. The diagnostic procedures and therapeutic interventions need to be individually tailored according to patient age, comorbidities and therapeutic aims.
There have been important developments in prognostication and therapy during recent years (e. g., significance of TP53 mutations, introduction of novel monoclonal antibodies and B-cell receptor signalling inhibitors). Therefore, the Czech CLL Study Group, the working group of the Czech Society of Haematology developed these updated guidelines to facilitate the decision-making process for diagnostic and therapeutic procedures in daily practice.
The guidelines are based on a comprehensive analysis of current literature and follow the principles of evidence-based medicine.