Vaginal fluid interleukin-6 concentrations as a point-of-care test is of value in women with preterm prelabor rupture of membranes

Abstract

The point-of-care assessment of interleukin-6 in vaginal fluid is an easy, rapid, non-invasive, and inexpensive method for the identification of intra-amniotic inflammation and microbial-associated intra-amniotic inflammation in preterm PROM pregnancies, showing good specificity and negative predictive value.

Keywords

• amniocentesis
• amniotic fluid
• biomarkers
• cytokine
• interleukin
• intraamniotic inflammation
• lateral flow-based immunoassay
• microbial invasion of the amniotic cavity
• noninvasive procedure
• preterm
• rapid test