Abstrakt
Colistimethate sodium (CMS) antibiotic is used for cystic fibrosis treatment caused by bacteria Pseudomonas aeruginosa. CMS can be administrated as a solution for nebulisation and recently as a dry powder for inhalation.
Dry powder inhalers (DPI) are able to deliver high payloads of drug within shorter times, easier to use, and involves much less time consuming administration compared with nebulisers. The aim of the study was to produce and characterise in detail dry powder of CMS for DPI administration.
The CMS formulation was prepared by spray drying and the properties of the spray drayed (SD) powder were characterized by Next Generation Impactor (NGI) for assessment aerodynamic properties, Spraytec for volume size distribution determination, X-Ray diffraction analysis, Thermogravimetric analysis and Differential scanning calorimetry for physical-chemical properties, and Scanning electron microscope for morphology assessment. The CMS concentrations in spray dried CMS powder were investigated using High Performance Liquid Chromatography.