ENETS Consensus Quidelines Update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms and neuroendocrine neoplasm of unknown primary recomend using somatostatin analogues for antisecretoric indication in functioning tumors and for antiproliferative indication (based on clinical studies) also in non-functioning tumors. Wait and watch aproach is now used less often.