Fractal aspects of the flow and shear behaviour of free-flowable particle size fractions of pharmaceutical directly compressible excipient sorbitol

Abstract

The influence of particle size on the mass flow rate through the orifice of a conical hopper, and the cohesion and flow function was studied for four free-flowable size fractions of sorbitol for direct compression in the range of 0.080-0.400 mm. The best flow properties of the fraction 0,245 mm were detected.

Keywords

• flowability
• size fraction
• sorbitol for direct compaction
• Jenike shear tester
• fractal dimension