Subjective spatial navigation complaints are associated with regional brain atrophy and APOE in elderly with subjective memory impairment

Abstract

Subjective memory complaints (SMC) may confer higher risk of developing Alzheimer's disease (AD) known for its spatial navigation impairment. Whether subjective spatial navigation complaints (SSNC) associate with objective impairment in SMC subjects is unknown.

We analyzed relationship between SSNC and brain atrophy in SMC compared to aMCI patients and controls.

Keywords

• spatial navigation
• brain atrophy
• Alzheimer's disease