Expression of ATP - binding cassette proteins Pgp, MRP1 and MRP3 in malignit and bening ovarian lesion

Abstract

The highest expression of Pgp and MRP1 was found in ovarian tumor cells compared to expression in the lining of the ovarian cyst. The lowest expression was documented in normal ovarian tissue.

The histological subtype of epithelial ovarian cancer correlated with the expression of PgP, MRP1, and MRP3

Keywords

• ATP- binding cassette proteins
• ovarian cancer
• Pgp
• MRP1
• MRP3
• drug resistance