Substituted 2-(2-phenylhydrazinyl)pyrazine, process of its preparation, its use and pharmaceutical composition containing thereof
Abstract
The present invention relates to substituted 2-(2-phenylhydrazinyl)pyrazine of the general formula I, in which each Re1, Re2 represents independently on each other H or CN; Re3 denotes CHi3 or CONHi2; each Re4, Re5, Re6, Re7, Re8 represents independently on each other H, Cl, or NOi2. The invention further relates to a process for preparing the above-indicated substances, which preparation process is characterized in that a corresponding substituted chloropyrazine is brought into reaction with substituted phenylhydrazine under conditions of microwave synthesis.
The compounds of the general formula I exhibit low toxicity and high activity against mycobakteria. They can also be used in pharmaceutical compositions as antituberculous drug.