This issue of the Zaostřeno ("Focused") bulletin provides a summary of major findings and trends concerning substance use which were published in the Annual Report: The Czech Republic - 2015 Drug Situation. It outlines the current situation and latest developments in drug policy, describes the results of studies of the scope and patterns of drug use, and provides up-to-date information pertaining to the domains of prevention, treatment, and harm reduction, as well as reporting on the developments in drug-related crime and current tendencies on drug markets.