Abstract
Targeted therapy is currently an integral part of medical practice in many fields of medicine. In pulmonary medicine is targeted therapy recognized in therapy of cancer, asthma bronchiale, idiopathic pulmonary fibrosis.
Targeted therapies is aimed at a specific target, in most cases the cell receptors and their ligands, whose genes are in individual diseases frequently altered as a result of amplification, mutation, deletion, translocation and various epigenetic changes. Targeted drug operates at a subcellular level, affects basic control functions of cells - proliferation, differentiation, migration, apoptosis and angiogenesis.
By inhibiting this goal, which plays a critical role in the pathogenesis of a particular disease, can suppress these events. The trend in deciding on the treatment strategy is tailored therapy, which means that we choose the right drug for the right patient at the right time and at the right dose.
It is necessary (especially in oncology) to know the molecular profile of the disease, which means that we need to identify markers that are crucial for the choice of treatment and its effectiveness. A new direction in targeted therapy, particularly cancer, is immunotherapy whitch using certain parts of a person's immune system to fight diseases such as cancer.