Abstract
Monoclonal gammopathy are a heterogeneous group of disorders. They are characterized by proliferation of one clone differentiated B-cells producing the monoclonal immunoglobulin (Ig-M).
Monoclonal immunoglobulin (M - protein, M - component, paraprotein) consists of both an intact immunoglobulin molecule or also only of the structural component, i.e. light chain kappa or lambda, rarely heavy chain. The basic investigative methods of detection of the monoclonal immunoglobulin belong electrophoresis of serum protein and immunofixation electrophoresis.
Another vital and important technique in the diagnosis and monitoring of the monoclonal gammopathies is the determination of free light chains. Our report provides an overview of newly diagnosed monoclonal gammopathy of a regional laboratory for the past 8 years