Thrombophilia testing results in patients with a first venous thromboembolic event: should the selection criteria for testing be revisited?

Abstract

After the first episode of venous thromboembolism (VTE), the guidelines recommend selective thrombophilia testing and suggest not to test the patients older than 40 years with a provoked event and all patients above 60. We compared thrombophilia workup results in 544 patients, meeting or not meeting the selection criteria.

Homozygous factor V Leiden or prothrombin gene mutation, natural anticoagulant deficiencies, antiphospholipid syndrome or combination of GREATER-THAN OR EQUAL TO2 disorders were considered a strong thrombophilia.

Keywords

• Venous thromboembolism
• Thrombophilia
• Testing
• Patient selection