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Nasal oxytocin as anxiolytic agent before stomatology treatment

Publikace

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

After ethic committee and patients' consent, patients scheduled for extraction of lower third molar were included in an open study. Exclusion criteria were pregnancy and ASA classification >2.

Oxytocin 5 IU (10 mcg) was administered by MAD100 micronebuliser to both nostrils. Visual analogue scale (0 - 10) was used for measuring level of anxiety before administration and in 15 minutes intervals.

Blood pressure, pulse, SpO2 and changes in skin resistance were measured in 5 minutes intervals during study. All measurements were performed for 2 hours.

Paired t-test and ANOVA test were used for statistical analysis. P value <0.05 was considered significant.

There was a significant decrease of anxiety in all patients (from VAS 5.6+-1.7 to VAS 1.5 +- 0.3, p<0,001). The difference was significant only in the first measurement compared to pre-administration value; Nasal oxytocin can be used as premedication before dental treatment.