Abstract
After ethic committee and patients' consent, patients scheduled for extraction of lower third molar were included in an open study. Exclusion criteria were pregnancy and ASA classification >2.
Oxytocin 5 IU (10 mcg) was administered by MAD100 micronebuliser to both nostrils. Visual analogue scale (0 - 10) was used for measuring level of anxiety before administration and in 15 minutes intervals.
Blood pressure, pulse, SpO2 and changes in skin resistance were measured in 5 minutes intervals during study. All measurements were performed for 2 hours.
Paired t-test and ANOVA test were used for statistical analysis. P value <0.05 was considered significant.
There was a significant decrease of anxiety in all patients (from VAS 5.6+-1.7 to VAS 1.5 +- 0.3, p<0,001). The difference was significant only in the first measurement compared to pre-administration value; Nasal oxytocin can be used as premedication before dental treatment.