The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance
Abstrakt
Aims. To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters Methods.
MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffinembedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis.
Results. Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative.
The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P= 0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients.
Conclusion. A tendency to differences in the survival of patients with ACC, depending on their MYB status.
MYB negative patients were predisposed to better prognosis.