Publication at Faculty of Pharmacy in Hradec Králové |
2016
Abstract
The movement of drugs within the organism and their concentration in the target issue are determined by their ability to cross biological membranes and barriers. Movement across membranes may involve many different mechanisms.
The article characterizes individual types of drug transport across biological membranes and barriers and offers examples of drugs in which these transport mechanisms are clinically relevant. Possible significance of transport mechanisms for both drug pharmacokinetics and effect/toxicity is also reviewed.