Abstract
The research is focused on searching of biological markers of the disease, which can be easily examined in blood samples. Aim of this study is to find out the association between changes in energy metabolism and different episodes of bipolar affective disorder (BAD).
Selected mitochondrial parameters (citrate synthase and electron transport chain complexes activities, and mitochondrial respiratory rate) were measured in peripheral blood components. Analyses were provided in patients with BAD in different states of the disease (in period of mania, depression and remission) and compared to healthy controls.
Our preliminary results showed increased complex I activity in BAD patients in the manic episode and remission compared to controls. Physiological mitochondrial respiration rate in intact platelets was found increased in BAD patients in remission compared to healthy volunteers.
Our results support the hypothesis that changes in the rate of mitochondrial oxygen consumption and electron transport chain complexes activities may participate in pathophysiology of BAD.