Publication at Faculty of Medicine in Hradec Králové |
2017
Abstract
This review article analyzes contribution of experimental research for understanding of mechanisms of cardiotoxicity of anticancer drugs and options for cardioprotection. We focused on drugs inducing direct toxicity towards cardiomyocytes resulting into the left ventricular dysfunction.
Typical features of Type I and II toxicity (represented by anthracyclines and trastuzumab/sunitinib, respectively) are discussed. Furthermore, in vivo models for experimental study of anthracycline cardiotoxicity are described.