Abstract
Antituberculotically active substances based on dinitrophenyl oxadiazole or -triazole of the formula I, where X = O or NR2; when X = O, then Y = S or NH, or when X = NR2, then Y = S; R1 = H-, C1-C11 alkyl, phenyl or phenyl- substituted in positions 2, 3, 4 and 5 with one or more electron acceptor or electron donor groups and R2 = CH3- or PhCH2- with the exception of the compound 2-(3,5-dinitrophenyl)-5-(3,5-dinitrobenzylsulfanyl)-1,3,4-oxadiazole and 2-(3,5-dinitrophenyl)-5-(2,4-dinitrobenzylsulfanyl)-1,3,4-oxadiazole. These compounds can be prepared by simple syntheses and are characterized by low toxicity and high effectiveness against mycobacteria, including their multiresistant strains.
The invention deals with a pharmaceutical preparation comprising dinitrophenyl oxadiazole or -triazole of formula I as an active ingredient, as well as the use of this dinitrophenyl oxadiazole or -triazole as antituberculotics.