Abstract
The term "non-traditional method of administration" can refer to nasal, oral mucosal, conjunctival and transdermal application and by inhalation. Methods are noninvasive, in some cases we even observe an improvement in pharmacological profile of drugs.
Some drugs have been administered using non-traditional methods, others are waiting for their introduction to the medical practice. In this monograph, the scholars present their original and extensive experimental research into non-traditional methods of applying ketamine, etomidate, opioids, benzodiazepines, α2-sympathoadrenergic and anticholinergic drugs, and oxytocin, and their combinations in experimental animals.
They also contain comments on previously published results in humans. They pay special attention to specific antagonists, such as flumazenil, sarmazenil,atipamezole, naloxone and naltrexone.
Many drugs and their combinations had not been previously tested and this monograph is the first to publish these results.