Comparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity

Abstract

A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae.

Keywords

• Carbapenemase
• antibiotic resistance
• MALDI-TOF MS
• meropenem
• imipenem
• VIM
• IMP
• GES