Treatment-resistant depression II: basic principles and strategies of treatment

Abstract

Depressive disorder is associated with a significant burden and costs to the society and patients. Remission of depressive disorder is achieved in only one-third of the patients after the first antidepressant trial.

The present article provides a summary of the therapeutic pharmacological and neurostimulation strategies that have been evaluated for treatment-resistant depression.

Keywords

• treatment-resistant depression
• treatment strategy
• optimization, switch therapy, augmentation, neurostimulation methods