Sequential Oxidative and Reductive Radical Cyclization Approach toward Asperparaline C and Synthesis of Its 8-Oxo Analogue

Publication at Faculty of Science |

2017

Abstract

The most advanced approach, so far, to the asperparalines is developed. Consecutive oxidative and reductive radical cyclizations serve as the key steps to stereoselectively access the complex fully elaborated skeleton containing the cyclopentane and spiro-succinimide units.

Keywords

prenylated indole alkaloids chiral tetracyclic indolidines Aspergillus Japonicus JV-23 Diels-Alder cycloaddition Pauson-Khand reaction enantioselective synthesis stephacidin alkaloids unactivated alkenes addition-reactions malbrancheamide B

Sequential Oxidative and Reductive Radical Cyclization Approach toward Asperparaline C and Synthesis of Its 8-Oxo Analogue

Abstract

Keywords

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