Hematopoiesis in patients with mature B-cell malignancies is deregulated even in patients with undetectable bone marrow involvement
2017
Abstract
Mature B-cell malignancies represent the most common types of hematologic tumors. Despite this, little information is available on the composition and function of hematopoiesis in patients with these malignancies.
Hematopoietic stem and progenitor cells (HSPCs) might be influenced by at least three key factors: 1. HSPCintrinsic mutations (that might predispose subjects to the development of these malignancies), 2.
Direct or indirect impact of malignant lymphocytes present in the bone marrow (BM) or extramedullary tissue, and 3. Age-related changes.
The aim of the study herein was to analyze HSPC content in patients with thus far untreated mature B-cell malignancies.