MiR-155/miR-150 network regulates progression through the disease phases of chronic lymphocytic leukemia

Abstract

Chronic lymphocytic leukemia (CLL) is a slowly developing progression-prone disease. MicroRNAs miR-155 and miR-150 are small inhibitors of gene expression in B-cells that were previously connected to the pathogenesis of CLL.

We herein evaluated relationship of miR-155/miR-150 network with clinical and routine laboratory parameters of the CLL patient cohort utilizing multivariate analyses and found its association with overall survival and progression of CLL.

Keywords

• c-myb
• expression
• differentiation
• survival
• cells