The combination of levodopa / carbidopa / entacapone in the treatment of patients with advanced Parkinson's disease
2017
Abstract
Two case studies deal with patients with advanced Parkinson's disease. Their conclusions point to the importance of prolonging the effect of levodopa, in this case entacapone, in wearing-off patients who do not agree to shorten the dose interval to 3 hours.
They point out how very difficult and important to find a balance between drug dosing leading to off status and dyskinesia at the top of the dose