Abstract
Hemiplegic migraine is a very rare disease with a prevalence of 0.01%. This is the first type of migraine with a proven gene defect in chromosomes 19.1 and 19.2.
The clinical picture typically includes motor impairment up to plegia (days to weeks). Triptans are not recommended in therapy, non specific antimigraine medicaments are preferred.
For prolonged course of the disease, prophylactic treatment is recommended. In differential diagnostics, we consider CMP, epileptic seizures, other types of migraines, neuroinfections, or rarer clinical units such as CADASIL or MELAS.