Abstract
Diabetes mellitus (DM) is a heterogeneous primary disorder of sugar metabolism, which is characterized by absolute or relative insulin deficiency. The clinical picture of this serious illness includes, among other things, disorders of the cardiovascular system, which are also the most common cause of death in diabetic patients.
There was an increased incidence of heart failure attributable to ischemic heart disease or hypertension. Diabetic cardiomyopathy, however, may develop independently of increased blood pressure or coronary artery disease by arteriosclerotic process, as the changes in the internal environment of diabetic individuals damage the heart.
Characteristic features are the structural and functional changes of the myocardium, which were also studied by using of experimental animal models. Clarification of the mechanisms, that are the cause of these pathophysiological changes, is the basis for establishing a new pharmacological strategy for the treatment of diabetic patients.