Compounds based on cyclam, their conjugates, targeting conjugates, coordination compounds, pharmaceutical formulations containing them, modes of their preparation, and their utilization
Abstract
The patent covers synthesis of bifunctional derivatives of cyclam containing bis-phosphinic group. These ligands are further conjugated to various biologically active molecules.
The ligands and their conjugates are labelled with metal radioisotopes. Mainly, i tis focused on copper radioisotopes.