Historical injection solutions of quinine analyzed by HPLC/MS

Abstrakt

Two injection solutions of quinine 79, 77 resp., years were analyzed using RP-HPLC. The conditions of separation were optimized.

The quinine content is decreased about 13% for 79-year-old sample and about 8% for 77-year-old sample, respectively. Quinotoxine has been found as the decomposition product.

The compounds were identified by MS 2, and the ESI fragmentation mechanisms of compounds found were proposed.

Klíčová slova

• high-pressure liquid chromatography
• decomposition
• long-term stability
• mass spectrometry
• quinotoxine