Behavioral effects of antiepileptic drugs in rats: Are the effects on mood and behavior detectable in open-field test?

Abstract

Behavioral side effects of antiepileptic drugs (AEDs) are common. The study evaluated behavioral patterns in rats after administration of lamotrigine, levetiracetam, phenytoin, topiramate, carbamazepine, gabapentin, pregabalin, and zonisamide.

Significant differences between AEDs in terms of their behavioral profile were found.

Keywords

• Antiepileptic drugs
• Open-field test
• Behavior
• Anxiety