Abstract
Monosymptomatic nocturnal enuresis (MNE) is a common disease in childhood. Enuresis has a significant impact on the child and its family quality of life.
In some cases treatment fails. The most common causes of a failure are: low patient's adherence to treatment, misdiagnosis of other underlying pathology and incorrect use of therapy.
Repeated child and its parents' education, detailed reexamination aiming to rule out all possible missed pathologic conditions and detailed of previous therapy are the key points of success. The treatment should follow the International Children's Continence Society recommendations.
The first line treatment is represented by enuretic alarm and/or desmopressin, the second line includes administration of anticholinergics, line treatment is represented by enuretic alarm and/or desmopressin, the second line includes administration of anticholinergics, imipramin should only be used as a third line treatment.