Apixaban - a direct, oral, selective activated factor Xa inhibitor - has been approved since the year 2014 for the treatment ofacute venous thrombosis and the so-called low-risk pulmonary embolism (in addition to the registration for the prevention ofsystemic embolization in non-valvular atrial fibrillation and the prevention of venous thromboembolism in orthopaedics). It isan effective and very safe option for oral monotherapy since the establishment of the diagnosis of thromboembolic disease inboth outpatient and inpatient settings.