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The rare cause of a secondary Cushing syndrome

Publication at First Faculty of Medicine |
2017

Abstract

The case report documents a 42 years old man who was diagnosed with ACTH dependent Cushing syndrome and a pituitary microadenoma. ACTH overproduction and consequent hypercortisolism persisted even after a transnasal resection. 18F-DOPA PET/CT detected a lesion in the right pulmonary hilum that was surgically removed.

The histology proved a typical carcinoid tumor. Paraneoplastic etiology represents 5-10 % cases of Cushing syndrome, which is most frequently caused by pulmonary neuroendocrine tumors - a carcinoid tumor and a small cell bronchogenic carcinoma.