Publication at Faculty of Medicine in Hradec Králové |
2017
Abstract
Human papillomavirus (HPV) has been known as the main etiological factor of cervical carcinoma already in 1983. Since then, HPV is recognized in relation with carcinomas of other organs of anogenital tract and also of the head and neck region.
Recently, it became obvious that HPV-associated squamous cell carcinomas differ significantly from the HPV-negative ones - in thein epidemiology, biological behavior and prognosis. Therefore, HPV testing of tumor tissue becomes clinically important.
There is a number of methods for HPV detection, with varying requirements for the biological matherial and also for their sensitivity, validity and cost. According to these differences, it is important to select optimal method for HPV detection.