Abstract
The aim of this paper is summarize information about the role of proteolytic enzymes in the human body up to date. Proteolytic enzymes control of the cell cycle, cleave peptide bonds, play key roles in many pathophysiological processes, and are targets for therapeutic strategies.
This review shows the role these enzymes at 1st physiological state, 2nd dysregulation of proteolysis associated with different diseases and 3rd proteases as potential biomarkers that can be used for diagnostic purposes. Proteases play critical roles in a plethora of biological processes such as development, differentiation and cell migration.
The essential role of proteases is large number conversion reactions from an inactive precursor into a biologically active principle. Since the function of a proteases is to cleave proteins and peptides, their action could be controlled.
Human plasma proteinase inhibitors and limited proteolysis are important for regulation. Basic knowledge of mechanism of regulation by proteases are essential to analysis of number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases, thereby suggesting proteases as suitable and valuable drug targets.