Determination of a Novel Antimycobacterial Agent in a Single Drop of a Solution by Voltammetry at a Glassy Carbon Electrode
2017
Abstract
One of the novel antimycobacterial agents from the group of hydroxynaphthalene carboxamides (namely 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide) was investigated using voltammetric methods for the first time. The study was carried out at a glassy carbon electrode by methods of cathodic and anodic differential pulse voltammetry in micro volumes (20 μL) of an aqueous solution at pH 7 containing 10% dimethyl sulfoxide and in a real matrix of a bacterial growth medium.
The miniaturized method was compared with the macro volume determination. The presence of oxygen in micro volumes presents the biggest obstacle for the miniaturized method.