The aim of this founding conference of the Institute for Study of Strategic Region (ISSR) is to gather and confront different approaches to research on broadly understood concept of a "region" and demonstrate its potential for our understanding of contemporary world in its historical, cultural and geopolitical terms. An important part of the discussion will also comprise different approaches to terminology and methodology outside the boundary of "regional" and "area" studies as they have been commonly practiced until now, and considerations of efficient transdisciplinary collaboration between social sciences and humanities.