Publication at Faculty of Medicine in Hradec Králové |
2017
Abstract
For patients with lung carcinoma it is fundamentally important to identify the individual molecular subtype of non-small cell lung carcinoma (NSCLC). Tumors with reconstruction of ALK-gene, which form 4-6% of adenocarcinomas, appear as a specific subgroup.
The optimal method to identify ALK-positive patients is immunohistochmistry (IHC) complemented in certain cases by FISH. Sole responsibility for selection of material for testing lies on the pathologist who closely cooperates with a molecular biologist.