Abstrakt
The many negative side effects of drugs used for treatment of highly diverse diseases, such as cancer, lead in recent years to the development of ways how to target the drug selectively to the diseased tissue while avoiding the healthy cells. Nanocarriers, made from various materials, can serve as a suitable platform for this targeted drug delivery.
Herein, we evaluate the long-term stability of nanocarrier based on ubiquitous protein apoferritin with encapsulated doxorubicin. Various properties of the nanocarrier were observed over the course of 12 weeks while stored at various temperatures, such as premature drug release, optical properties of the encapsulated drug, nanocarrier size and surface zeta potential.
The nanocarrier showed very good stability for up to 12 weeks with the best results observed with nanocarrier prepared in water and stored at dark at 4 degrees C.