Characterisation of a ST100 Staphylococcus epidermidis producing an LnuB nucleotidyltransferase: Evidence for interspecies spread of an lnuB-carrying transposon
2018
Abstract
The increasing emergence of staphylococci resistant to lincosamides is a growing public health concern worldwide. The majority of lincosamide-resistant staphylococci also exhibit resistance to macrolides and streptogramin B (MLSB phenotype) and are positive for the presence of erm-like genes, whilst a few staphylococci are resistant only to lincosamides either due to an efflux pump (lsa gene, etc.) and/or to an inactivating enzyme (lnuA, lnuB).
Here, the structure of the first lsaE/lnuB-positive Staphylococcus epidermidis strain, isolated in Greece, is described and is compared with previously published genetic environments.